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QBD 1



Quantum Brain Dynamics




1.) Introduction

2.) Quantum Brain Dynamics & Consciousness - Jibu & Yasue



Introduction:

Quantum Brain Dynamics

The basic concept in quantum brain dynamics (QBD) is that the electrical dipoles of the water molecules in the brain constitute a cortical field. The quanta of this field are described as corticons. The field interacts with quantum coherent waves propagating along the neuronal network. There is more than one view within QBD as to how this system supports or instantiates consciousness.

The ideas behind quantum brain dynamics (QBD) derived originally from the physicists, Hiroomi Umezawa and Herbert Frohlich  in the 1960s. In the last 20 years, these ideas have been elaborated and given greater prominence by the combined efforts of Japanese physicists, Mari Jibu and Kunio Yasue and the Italian physicist, Giuseppe Vitiello.

Umezawa along with Iain Stuart and Yasushi Takahashi (12.) proposed the idea of a cortical field in the brain. Water comprises 70% of the brain, and QBD proposes that rather than providing a passive background, water could be an active player in brain processes. Water molecules have a constant electric dipole, and are considered in QBD to be capable of interacting with waves generated by biomolecules that are also electrical dipoles.

In QBD, the totality of the water molecules in the brain is viewed as the best candidate for a cortical field, with the water’s electrical dipoles binding both to one another and to the biomolecules of the neuronal network. There are also suggested to be long-range waves within the cortical field. The quanta of the cortical field are given the name of corticons, and in Jibu and Yasue’s version of the theory, the interaction between the cortical field and the neuronal network, particularly the dendritic part of that network, is the basis of consciousness.

The other half of the theory refers to biomolecules propagating through the neuronal network, an idea deriving from the work of Frohlich in the 1960’s. Frohlich argued that it was not clear how order was sustained in living systems, given the likely disrupting effect of the fluctuations in biochemical processes (3., 4. & 13.). His ideas relate mainly to the ordering of the neuronal network, on which the proposed cortical network of Umezawa is proposed to act.

Frohlich saw the electric potential across the cell membrane as the macroscopic observable of an underlying quantum order. Frohlich’s studies claim to show that with oscillating electrical charges in a thermal bath, a large number of quanta may become condensed into a single state, known as a Bose condensate, allowing long-range correlations amongst the dipoles involved. He also proposed that biomolecules with a high electric dipole moment line up along the actin filaments, and that electric dipole oscillations propagate along these filaments in the form of quantum coherent waves. There is some support for these ideas, in the form of experimental confirmation that biomolecules with high electric dipole moment have a periodic oscillation (14. Gray & Singer, 1989)
.

Vitiello agrees with Frohlich in arguing that living systems constitute ordered chains of chemical reactions, which could normally be expected to collapse in the random chemical environment of biological tissue. In Vitiello’s view stable ordering comes from the quantum level, but this is described by quantum field theory rather than quantum mechanics. He also claims that the folding of protein, which is fundamental to the activity of cells, cannot be described by classical physics, but could be quantum ordered.

Vitiello provides citations, which he feels support a quantum dynamical view of biological tissue, notably studies of radiation effects on cell growth by (15. Grundler & Kaiser, 1992) & (16. Pohl, 1988), on electromagnetic fields and stress by (17. Gutzeit, 2000), on dynamical response to external stimuli by (18. Kaiser, 1988), on non-linear tunnelling by (19. Huth et al, 1984), on coherent nuclear motion in membrane proteins by (20. Vos et al, 1993), on optical coherence in biological systems by (21. Li et al, 1983), on weak radiation fields and biological systems by (22. Popp, 1986) & (23. Jerman et al, 1996) and on energy transfer via solitons and coherent excitations by (24. Huth, Gutman & Vitiello, 1989) & (25. Christiansen, Pagano & Vitiello, 1991).

QBD proposes that the cortical field not only interacts with, but also to a good extent controls the neuronal network. It suggests that biomolecular waves propagate along the actin filaments, an important part of the cytoskeleton, particularly in the vicinity of the cell membrane and dendritic spines. The waves derive energy from ATP molecules stored in the membrane, and these in turn are controlled by calcium ions. These waves are also suggested to control the action of ion channels, which are crucial in the transmission of signals to the synapses.. The neurons membrane is further suggested to act as a Josephson junction providing insulation between two layers of superconductivity. The superconductivity current across the membrane can be controlled by the electrical potentials across the same membrane.

Vitiello also discusses the question of quantum decoherence. He claims that QBD only requires quantum oscillations to last 10-14 picoseconds, which should be much shorter than the period required for decoherence (26. Del Giudice, Preparata & Vitiello, 1988b). In common with Stuart Hameroff, he additionally argues that ordered water around protein molecules may shield them from the surrounding thermal bath.

Jibu & Yasue appear to see consciousness as simply a function of the interaction of the corticons, the energy quanta which are proposed to arise in the cortical field, with the biomolecular waves of the neuronal network. Vitiello, while thinking in terms of much the same quantum systems as Jibu and Yasue, proposes that these quantum states produce two poles, first a subjective representation of the external world and secondly a self, which opens itself to this representation of the external world. According to Vitiello’s version of the theory, consciousness is not strictly speaking in either the self or the external representation but between the two, in the opening of one to the other.






Quantum Brain Dynamics and Consciousness


Mari Jibu & Kunio Yasue


John Benjamins   ISBN 90 272 5123 1 (Eur)

The concepts behind this book derive from the Japanese physcist, Hiroomi Umezawa, who speculated that understanding the processes of memory in the brain would involve quantum field theory. This led onto the idea that understanding consciousness would also involve quantum field theory.
 
The first four chapters of the book provide a standard background to quantum theory and neuroscience. Those without some grounding would be better advised to look at more standard text books or popularisations, as the style of the book is generally difficult and unecessarily repetitive. The first four chapters of the book deal with quantum theory. For those not familiar with this, there are many much more comprehensible descriptions. This is followed by some descriptive passages on the brain, which is again better described elsewhere.
 
Getting beyond these introductory stages, the authors make the same point as others in strssing the estrangement between physics, where fundamental new views of nature emerged during the last hundred years and neuroscience which has remained largely wedded to 19th century physics. In particular physics has tended to think dynamically, in terms of controlled changes. Physics deals primarily with the inanimate, but the concepts of dynamics can be applied to living organisms, as they also undergo controlled changes. 

The authors suggest that the functions of the cortex might be better understood through the dendritic network, by which information enters cells. They stress that many neurons in the cortex do not have axons but only dendrites. They think that the conventional processing system described in the axon-neurotransmitter-dendrite system may overlook other networks in the brain. Neurons without axons are the majority in the cortex and the authors see these as the likely basis of consciousness.

The authors discuss the dendritic network at length. They point out that it is much more sophisticated than the axonal network. The dendritic membrane comprises biomolecules with electric dipoles, the positive poles of the membrane are aligned on the inner surface and the negative poles on the outer surface.. Th negative poles on the outer surface attract positive ions, while the positive poles on the inner surface attract negative ions. The regions where these interactions occur are called Debye layers. The dendrites of several neurons are often entangled in a network. Chemical synapses are located on the tips of dendritic spines and there are ephases on the dendritic membranes.

There is experimental confirmation that biomolecules of high electric dipole moment have a periodic oscillation (Fröhlich, 1968), (Gray & Singer, 1989) (1&2) The authors suggest that these oscillations are crucial to the functioning of the brain. This can be called wave cybernetics, because the wave or biomolecule oscillation is seen as the controlling factor in the brain.

Frohlich proposed a theory where biomolecules with high electric dipole moment line up along the actin filaments immediately below the cell membrane, while electric dipole oscillations propagate along each filament as coherent waves. These are maintained by electrons trapped in and moving along the protein molecules. This is now known as a Frohlich wave. These waves exchange energy with the electromagnetic field. There is some experimental support for Frohlich waves (Genberg et al, 1991), (Genzel et al, 1976), Webb & Stoneham, 1977), (Webb, 1980).

Umezawa, Stuart and Takahashi proposed the idea of a cortical field. This interacts with the macroscopic dynamics of the main neural network, which in turn transmits signals to the body tissues. The filamentous strings found in the cells also extend outside the cells forming an extracellular matrix that is also linked to the cell membrane. So the membrane proteins are linked both to the cytoskeleton and the extracellular matrix.
 
The authors propose that Fröhlich waves propagate along the filamentous strings. The waves are produced by energy stored in ATP molecules at membrane protein sites, which are in turn controlled by calcium ions. The waves also effect the operation of ion channels, which control neural impulses. The authors suggest that this structure can give rise to a macroscopic quantum phenomena, similar to superconductivity. They also regard the cell membrane as an insulating layer between two areas of superconductivity, otherwise known as a Josephson junction. This means that superconductivity current across the Josephson Junction can be controlled by electric potential differences in the insulating layer.
 
The authors suggest that this quantum activity may facilitate the functioning of the brain and in particular an interface between the proposed cortical field and the neurons network. The cortical field is proposed to contain energy quanta behaving as particles, which the authors call corticons. Corticons are suggested to exist everywhere in the cerebral cortex. The interface between the cortical field and the neuron network takes place in the waves propagating along the filamentous strings in the cytoskeleton and the extracelular matrix.


The authors emphasise the nature and importance of water within the brain. They suggest that water is not just a background substance, but is an active component in cell assemblies. This idea lies behind the original concept of the cortical field and corticons. The water molecule has a constant electrical dipole. It also has a symmetrical form that is invariant under reflection. The molecule rotates around its symmetry axis, which is the electrical dipole. Thus the molecule is a quantum mechanical spinning top, which interacts with the fields generated by biomolecules.
 
The totality of water molecules in the brain is seen as the best candidate for the sought for cortical field. In water, one side of the molecule becomes negatively charged, and one side positvely charged creating an electric dipole. This is an attraction between molecules known as hydrogen bonding. The attraction is both between water molecules and between water molecules and other molecules with electrical dipoles. Biomolecules such as proteins have constant electric dipoles and connect to water molecules.

The cortical field is identified with the water rotational field, created by the spinning dipoles of the water molecules. The field on the cytoskeleton and extracellular matrix is proposed to be a Bose field, and the interaction between this Bose field and the corticons of the cortical field is seen as the basis of consciousness. Corticons are identified with the energy quanta of the water rotational field of the brain. The corticons interact with each other by emitting and absorbing the exchange bosons of the bose field, and are themselves the energy quanta of the warer rotational field. The water rotational field is a dipole field andtherefore interacts with an electromagnetic field. There are also suggested to be long-range correlation waves in the water rotational field of the brain.
 
The brain structures described here are thought to be sensitive to and to modify themselves in responses to information coming into the brain. The combined dynamics of the cortical field and the electromagnetic field comprise what the authors describe as quantum brain dynamics (QBD). The dynamics of the corticons is thought to be capable of controlling the dendritic and neural networks. The authors think that the creation and annilihation of corticons in the QBD is what is called consciousness.
 
Unfortunately the authors do not explain why they think this, and therefore like more mainstream theories of consciousness, the actual consciousness seems to be created by fiat. There is no more apparent reason why consciousness should arise from this physical interaction than from the physical interaction of electrical potentials and chemical in the synapses. The authors could have suggested that consciousness was a fundamental property of photons or of the proposed corticons or of particular fields but they do not do this.

References:-

Bohm, D. (1951)   Quantum Theory   Prentice Hall

Bohm, D (1952)   A suggested interpretation of quantum theory in terms of hidden variables   I & II Physical Review 85, 166-179 and 180-193

Bohm, D. )1980)   Wholeness and the Implicate Order   Routledge & Kegan Paul

Bohm, D. (1986)   A new theory of the relationship of mind and matter   Journal of the American Society for Psychical Research 80, 113-135

Eccles, J. (1986)   Do mental events cause neural events anologously to the probability fields of quantum mechanics?   Proceedings of the Royal Society of London B277, 411-428

Fröhlich, H. (1968)  Long-range coherence and energy storage in biological systems   International Journal of Quantum Chemistry 2, 641-649

Fröhlich, H. (1970)   Long-range coherence and the actions of enzymes   Nature, 228, 1093

Globus, G (1995)   Postmodern Brain   John Benjamins

Gray, C. & Singer, W (1989)   Stimulus-specific neuronal oscillations  Proceedings of the National Academy of Sciences 86, 1698-1702

Hameroff, S. (1987)   Ultimate Computing   North-Holland

Hiley, B. & Peat, D (1987)  Quantum Implications: Essays in Honour of David Bohm   Routledge Kegan & Paul

Jibu, M & Yasue, K. (1992)  A physical picture of Umezawa’s quantum brain dynamics    in, Cybernetics and Systems Research, ed. R. Trappl   World Scientific

Jibu, M & Yasue, K. (1993A)   Introduction to quantum brain dynamics  in, Nature , Cognition and System  ed, Carvallo, M.   Kluwer Academic

Jibu, M & Yasue, K. (1993B)   Intracellular quantum signal transfer   Cybernetics and Systems 24, 1-7

Jibu, M & Yasue, K. (1993C)   The basics of quantum brain dynamics    in, Rethinking Neural Networks  ed. K. Pribram  Lawrence Erlbaum

Jibu, M., Hagan, S., Hameroff, S. Pribram, K. & Yasue, K. (1994)  Quantum coherence in microtubules   Biosystems 32, 195-209

Penrose, R. (1989)   The Emperor’s New Mind   Oxford University Press

Penrose, R. (1994)   Shadows of the Mind   Oxford University Press

Pribram, K (1991)   Brain and Perception   Lawrence Erlbaum

Schrödinger, E. (1944)   What is Life?   Cambridge University Press

Stuart, C. Takahashi, Y. & Umezawa, H. (1978)  On the stability and non-local properties of memory   Journal of Theoretical Biology 71, 605-18

Stuart, C. Takahashi, Y. & Umezawa, H. (1979)   Neural memory as a macroscopic ordered state   Foundations of Physics 9, 301-327

Umezawa, H. (1993)   Advanced Field Theory: Micro, Macro and Thermal Physics   American Institute of Physics

von Neumann, J. (1966)  Theory of Self-Reproducing Automata   Illinois University Press

Watterson, J. (1987)  A role for water in cell structure   Biochemical Journal 248, 615-617

Wiener, N (1948)  Control and Communication in the Animal and the Machine  MIT Press

Yasue, K. (1978)   Quantum mechanics of non-conservative systems   Annals of Physics 114, 479-496

Yasue, K. (1980)   Schrödinger quantisation revisited   Letters in Mathematical Physics 4, 143-6

Yasue, K. (1981)   Quantum mechanics and stochastic control theory  Journal of Mathematical Physics 22, 1010-1020

Yasue, K. (1988)   Wave cybernetics  Physical Review A38, 2671-2673

Yasue, K. et al (1988)  Stochastic neurodynamics   Annals of the Institute of Statistical Mechanics 40, 41-59





Karl Pribram

Georgetown
University

Brain and mathematics

In Globus, G., Pribram, H. & Vitiello, G. Eds.  Brain and Being    John Benjamins

 Pribram stresses that the same mathematical formulations apply to a variety of databases, including brain processes, information, thermodynamics and quantum physics. The relationships can be portrayed by the Fourier transformation. The similarity implies that neural processes are based on relations between quantum events.

Pribram discusses two articles by another quantum mind theorist, Henry Stapp (Stapp, 1997a & b) (1-2) . Stapp took the view that the brain process was a search process for satisfactory responses conditioned by earlier experience. He envisages a point moving in a well that blocks out those brain states that are not good solutions, while not blocking out those that are good solutions. Classical solutions to this don’t work in the chaotic conditions of the brain. However, Stapp points out that quantum solutions will work because they can explore a superposition of all solutions.

Pribram notes that a number of publications have reported that quantum coherence characterises the oscillation of ions in neural ion channels. Pribram relates the 'double' suggested by Vitiello, which comprises the external world and the internal, so-called tilda copy. Pribram also refers to George Chapline, who suggested that quantum theory presented a method for solving pattern recognition problems and that it could be a model for the type of distributed information processing carried out in the brain.

References:-

Adey, W. (1987)    The modulation of brain tissue functions  In Adelman, G. Ed.  The International Encyclopaedia of Neuroscience

Barrett, T. (1993)    Is quantum physics a branch of sampling theory?  In Corrmier-Delanous, C. et al Eds.  Ecueilsen Microphysique  Fondation Louis DeBroglie

Bohm, D. (1973)    Indication of  a new order in physics    Foundations of Physics, 3, 139-168

Bohm, D. & Hiley, B. (1993)    The Undivided Universe    Routledge

Bohr, N. (1961)    Atomic Physics and Human Knowledge    Science Editions

Chapline, G. (1999)    Is theoretical physics the same thing as mathematics?    Physical Reports, 315, pp. 95-105

Chapline, G. (2002)    Entangled states, holography and quantum surfaces    Chaos, Solitons and Fractals, 14, 809-816

DeValois, R. & Devalois, K. (1988)    Spatial Vision    In Oxford Psychology Series    Oxford University Press

Fourier, J. (1807)    Sine and cosine series for an arbitrary function  In Joseph Fourier    MIT Press

Gabor, D. (1948)   A new microscopic principle    Nature, 161, pp. 777-778

Hameroff, S. & Penrose, R. (1995)    Orchestrated reduction of quantum coherence in brain microtubules  In King, J.& Pribram, K. eds.  Is the brain too important to be left to specialists to study?    Lawrence Erlbaum

Hebb, D. (1949)    The Organisation of Behaviour    Wiley

Hiley, B. (1996)    Mind and Matter  In Pribram, K. & King, J. Eds.  Learning as Self Organisation    Lawrence Relbaum

Hiley, B. (2001)    Towards a dynamics of moments  In Bowden, K. Ed.  Correlations, 23, pp.104-134

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Pribram, K. (1959)    On the neurology of thinking    Behavioural Science, 4, 265-287

Pribram, K. (1971)    Languages of the Brain    Prentice-Hall

Pribram, K. (1982)    Brain mechanisms  In Clynes, M. Ed.  Music, Mind and Brain, pp. 21-35    Plenum Press

Pribram, K. (1991)    Brain and Perception    Lawrence Erlbaum

Pribram, K. & Bradley, H. (1998)    The Brain, the Me and the I  In Ferrari, M. & Sternberg, J. Eds.  Self-Awareness, pp. 273-307    The Guildford Press

Pribram, K. (2004)    Consciousness reassessed    Journal of Mind and Matter

Shannon, C. & Weaver, W. (1949)    The mathematical theory of communications    The University of Illinois Press

Smolin, Lee (2004)    Atoms of space and time    Scientific American, vol. 290

Stapp, H. (1972/97)    The Copenhagen Interpretation    American Journal of Physics, 40 (8), 1098-1116

Vitiello, G. (2001)    My Double Unveiled    John Benjamins

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Wigner, E. (1972)    Time-energy uncertainty relation  In Salam, A. & Woolf, P. Eds.  Aspects of Quantum Theory





In Brain and Being

eds. Globus, G., Pribram, K. & Vitiello, G
.
Emilio Del Giudice

INFN

The psycho-emotional physical unity of living organisms as an outcome of quantun physics

Del Giudice discusses how quantum field theory (QFT) could provide an understanding of the pysche. Del Giudice starts his discussion at the point where classical 19th century physics was overtaken by quantum theory. He points out that at the very beginning of quantum theory Max Planck showed that matter had a  self-movement produced by quantum fluctuations and unrelated to any external influence. The phase describes the spontaneous oscillation of every quantum particle. Quantum particles and quantum fields, such as the electromagnetic field must oscillate. The quantum field cannot vanish completely, because there would be no fluctuation at an absolute zero, therefore the concept of a vacuum in classical physics is modified, and becomes a mass of fluctuations. There are two proofs of the existence of the underlying quantum fluctuations.
 
Firstly, there is the Lamb Shift, where measurements of the relationship between the proton and the electron in the hydrogen atom shows a discrepancy which is due to fluctuations in the elctromagnetic field. The second is the Casimir effect, where two metal plates set sufficiently close together exclude the long-wave quanta of the em field, which results in the inward pressure from the external space being greater than the pressure within the plates, proving the existence of vacuum energy.

Del Giudice puts forward the idea of the coherent domain. Every particle made up of charged components, as are all atoms and molecules, is coupled with the em field. Above a certain density and below a certain temperature, and at a lower energy than the gas state, these particles are suggested to enter a coherent state. Here the particles oscillate in tune with the em field that is trapped within the resonating particles. There is a coherent regime of matter and em field that prevails within a space that is the size of the em oscillations. This region is called a coherence domain (CD). Its size ranges from a fraction of a micron up to several tens of microns. Long range forces are suggested to occur at the boundaries of the coherent domains.

Del Giudice claims that analysis of many non-gases, such as water and crystals shows a good agreement with this thoery. The very limited acceptance of the idea is blamed on the tendency of the scientific community to confine its thinking to the ideas of classical physics. The author suggests that the large number sof CDs in living matter creates the possibility of finding the missing bridge between physics and biology. He suggests that the surface of the CDs could have molecules resonating with the surrounding water. The CDs are capable of giving rise to further CDs and these in turn to chemical reactions that by changing the molecules in the system also change the em field. The energy is not disippated in heat but instead produces a coherent excitation, which modulates the em field. This concept is seen as underlying the ordering of living matter. As such it provides us with a theory for life forms and possibly for information and cognition but not for consciousness as such. There is no reason why the property of consciousness should arise from the interchange with the electromagnetic field more than any other component of the physical universe, unless the theory is preapared to go the further step of specifying consciousness as a fundamental anf given property of the field or its quanta.

References:-

Bohm, David & Yakir, A. (1959)    Electromagnetic potentials in the Quantum Theory    Physical Review, 115, 485-491

Damasio, A. (1994)    Descartes Error    Putnam

Del Giudice, E., Doglia, S. Milani, M. & Vitiello, G. (1988)    Electromagnetic interactions in living matter  In Fröhlich, H. ed.  Biological Coherence and Response to External Stimuli pp. 49-64    Springer

Del Giudice, E., Doglia, S. Milani, M., Vitiello, G. & Smith, C. (1989)    Magnetic flux and Josephson behaviour in living systems    In Fröhlich, H. ed.  Biological Coherence and Response to External Stimuli    Springer

Del Giudice, E. & Preparata, G. (1995)    Coherent dynamics in water as an explanation of biological membranes    Journal of Biological Physics, 20, 105-116

Del Giudice, E. et al (2002)    Effects of weak magnetic fields on ions    Bioelectrmagnetics, 23, 522-530

Fröhlich, H. (1968)    Long-range coherence in biological systems    International Journal of Quantum Chemistry, 11, 641-645

Josephson, B. (1962)    Superconductive tunnelling    Physics Letters, 1, 251-253

Nernst, W. (1969)    The new heat theorem    Dover

Preparata, G. (1995)     QED coherence in matter    World Scientific

Preparata, G. (2002)    An introduction to realistic quantum physics    World Scientific

Zhadin et al (1998)    Static and alternating magnetic field on ionic current    Bioelectromagnetics, 19, 41-45